Decreased postoperative endophthalmitis rate after institution of intracameral antibiotics in a Northern California eye department. However, the cost-effectiveness of the use of intracameral antibiotics in reduction of the substantial costs associated with the treatment of POE after cataract surgery is well known [22]. The incidence of postoperative endophthalmitis after cataract surgery in China: a multicenter investigation of 2006-2011. eCollection 2022. All statistical analyses were conducted using Stata 12.0 software (Stata Corporation, College Station, TX, USA). As a library, NLM provides access to scientific literature. 2022 Aug 29;36(2):124-128. doi: 10.4103/sjopt.sjopt_44_21. The .gov means its official. Federal government websites often end in .gov or .mil. The results of the European Association of Cataract and Refractive Surgeons (ESCRS) report showed that the use of intracameral cefuroxime at the end of the cataract surgery significantly reduced the occurrence of postoperative endophthalmitis as well as improved the surgery techniques with the use of injectable lenses, topical anesthesia, and microincisions [3]. Epub 2012 Sep 12. Bethesda, MD 20894, Web Policies Studies that met the following inclusion criteria were included in the present systematic review and Meta-analysis: 1) prospective or retrospective studies evaluating the incidence of endophthalmitis after cataract surgery; 2) phacoemulsification technique was used for the removal of cataracts. 2022 Nov;70(11):4089-4091. doi: 10.4103/ijo.IJO_1166_22. Conclusions: During the study period, the total incidence of postoperative endophthalmitis after cataract surgery decreased significantly. Eye (Lond). Barreau G, Mounier M, Marin B, Adenis JP, Robert PY. Results: The infection's rate severity of spread depends on the pathogenic microorganisms' load and virulence[4]. Please enable it to take advantage of the complete set of features! The annual rate of presumed endophthalmitis after cataract surgery was calculated, and demographic risk factors for endophthalmitis were examined using multivariate models. doi: 10.1016/j.ophtha.2021.12.013. HHS Vulnerability Disclosure, Help In this meta-analysis, two antibiotics (cefazolin and cefuroxime) were evaluated. We would like to thank Barbara Wickowska Ph.D. for administrative support during the study period. This Meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement standards[14]. Copyright 2021 American Academy of Ophthalmology. government site. Incidence of endophthalmitis with intracameral. J Cataract Refract Surg. A detailed literature search was performed to obtain recently reported frequencies of postoperative endophthalmitis with or without the use of prophylactic intracameral antibiotics. Endophthalmitis occurs at a low incidence following cataract surgery (estimated to be between 0.012% 1.3%). Epub 2022 Jan 25. Incidence rate of endophthalmitis after cataract surgery and prevalence of demographic risk factors for endophthalmitis over an 8-year period. Kessel L, Flesner P, Andresen J, Erngaard D, Tendal B, Hjortdal J. Accessibility doi: 10.6061/clinics/2019/e837. Participants: The combined cataract surgery and male sex were significant risk factors for both acute and chronic POE. Online ahead of print. Friling E., Lundstrm M., Stenevi U., Montan P. Six-year incidence of endophthalmitis after cataract surgery: Swedish national study. Tanaka T, Ferreira BFA, Oliveira LMS, Kato JM, Gioia TSRD, Rossi F, Nakashima Y, Pimentel SLG, Yamamoto JH, Almeida Junior JN. Published by Elsevier Inc. All rights reserved. FOIA Jensen MK, Fiscella RG, Moshirfar M, Mooney B. Third- and fourth-generation fluoroquinolones: retrospective comparison of endophthalmitis after cataract surgery performed over 10 years. Figure 6. The incidence decreased from 0.49% in 2003 to 0.17% in 2006 and stabilized afterwards. Ophthalmology. 2016 Apr;100(4):446-52. doi: 10.1136/bjophthalmol-2015-307722. George NK, Stewart MW. Design: Clipboard, Search History, and several other advanced features are temporarily unavailable. A sensitivity analysis was performed to assess the robustness of the main Meta-analysis results. Garg P, Roy A, Sharma S. Endophthalmitis after cataract surgery: epidemiology, risk factors, and evidence on protection. Overall Incidence of Endophthalmitis After Phacoemulsification Cataract Surgery A total of 39 studies were included in the analysis of overall incidence of During the study period, the total incidence of postoperative endophthalmitis after cataract surgery decreased significantly, while the total the number of cataract surgeries significantly increased. 2023 Feb 14. doi: 10.1038/s41433-023-02440-z. Liu Z, Lin H, Jin L, Qu B, Liu J, Zheng Y, He M, Luo L, Liu Y. JAMA Ophthalmol. Bethesda, MD 20894, Web Policies Meta-analysis; antibiotics subconjunctival injections; endophthalmitis; intracameral antibiotics; phacoemulsification cataract surgery; typical povidone-iodine solution. Med Sci Monit. Perspectives on antibiotics for postoperative endophthalmitis prophylaxis: potential role of moxifloxacin. 2005 Nov;112(11):1884-9. doi: 10.1016/j.ophtha.2005.05.020. Medicare beneficiaries aged 65 years undergoing cataract surgery between 2011 and 2019. Epub 2015 Oct 21. Intraocular lens removal or not during vitrectomy for acute infectious endophthalmitis after cataract surgery. The overall 90-day postoperative endophthalmitis rate was 1.36 per 1000 cataract surgeries for all cataract procedures and 1.30 per 1000 cataract surgeries for stand-alone cataract procedures. official website and that any information you provide is encrypted According to results from 2021 American Society of Cataract and Refractive Surgery, intracameral antibiotics is suggested as an efficacious method of endophthalmitis prophylaxis[55]. and transmitted securely. This site needs JavaScript to work properly. Page MJ, Sterne JAC, Higgins JPT, Egger M. Investigating and dealing with publication bias and other reporting biases in meta-analyses of health research: a review. Members of the International Society of Bilateral Cataract Surgeons were surveyed. Wang XL, Huang XY, Wang Z, Sun W. The anterior chamber injection of moxifloxacin injection to prevent endophthalmitis after cataract surgery: a meta-analysis. and transmitted securely. 2023 Jun 1. doi: 10.1007/s00417-023-06121-1. Before Epub 2008 Dec 16. Accessibility The use of intracameral antibiotics administration will significantly reduce the risk of endophthalmitis. Gower EW, Lindsley K, Nanji AA, Leyngold I, McDonnell PJ. Postcataract surgery endophthalmitis in the United States: analysis of the complete 2003 to 2004 Medicare database of cataract surgeries. This site needs JavaScript to work properly. 2023 Jun 1;141(6):574-581. doi: 10.1001/jamaophthalmol.2023.1491. Bookshelf Results: In total, 1,218,777 cataract extractions (alone or combined with other procedures) were performed during 20102015. ), 8Department of Ophthalmology, Centre of Postgraduate Medical Education, 231 Czerniakowska str., Warsaw 01-416, Poland; moc.liamg@kerebili. Patients with a history of endophthalmitis 12 months before their cataract surgery procedure were excluded. One thousand twenty-six cases of presumed endophthalmitis occurred after 477,627 cataract surgeries, yielding an incidence rate of 2.15 per 1000 for this 8-year period. The https:// ensures that you are connecting to the Background: The assessment of the incidence and characteristic of acute and chronic postoperative endophthalmitis (POE) after cataract surgery in Poland during 20102015. Design Participants Methods Results = 0.01). When heterogeneity was high, random effects (DerSimonian and Laird method) were used as the analysis model, otherwise, the fixed-effects model (inverse variance method) was used[16][17]. The research period ranged from 1980 to 2017, and the follow-up period ranged from 0.5 to 6mo. Treatment of postoperative endophthalmitis (POE) after cataract surgery in Poland during 20102015. Postoperative endophthalmitis . official website and that any information you provide is encrypted Between the years 2010 and 2015, no simultaneous bilateral endophthalmitis was officially reported in Poland, since the legal regulations for immediate sequential bilateral cataract surgery (ISBCS) were introduced in January 2017. A nationwide study from 2005 to 2014. An updated estimate of costs of endophthalmitis following cataract surgery among Medicare patients: 20102014. During the study period, the use of an intracameral antibiotic injection at the end of the cataract surgery was not officially reported in the NFZ national database of hospitalizations as well as other possible risk factors such as surgical complications and the type of intraocular lens (IOL) used. Garat M, Moser CL, Martn-Baranera M, Alonso-Tarrs C, Alvarez-Rubio L. Prophylactic intracameral cefazolin after cataract surgery: endophthalmitis risk reduction and safety results in a 6-year study. eCollection 2022. Moser CL, Lecumberri Lopez M, Garat M, Martn-Baranera M. Prophylactic intracameral cefazolin and postoperative topical moxifloxacin after cataract surgery: endophthalmitis risk reduction and safety results in a 16-year study. Page MJ, McKenzie JE, Bossuyt PM, et al. Methods Of 111,876 vitrectomies (70,585 20-G 41,291 MIVS) performed, 45 cases developed acute-onset, postoperative Since cataract has the highest incidence among complications [10, 11], combined silicone oil removal and cataract (SORC) surgery with intraocular lens implantation is routinely considered in phakic eyes when silicone oil should be removed [1214]. In total, 7 were conducted before 2000, 19 from 2000-2010, and 8 after 2010. [ 2, 3] Bacterial infections are the most common cause of post-operative endophthalmitis, and Gram-positive isolates account for the majority of these cases. The total sample size for these studies was 5 878 114, ranging from 2674 to 2 424 038. Diagnostic value of pediatric blood culture bottles for acute postoperative endophthalmitis. The https:// ensures that you are connecting to the Complications Occurring Through 5 Years Following Primary Intraocular Lens Implantation for Pediatric Cataract. Purpose: Endophthalmitis is rare after cataract surgery, but it does occur and is vision threatening, with incidence rates ranging from 0.5 to 3.0 cases per 1000 cataract surgeries. The overall data-driven estimate of endophthalmitis incidence was 0.092%. These studies were conducted in 4 continents, with 19 in Europe, 13 in Asia, 5 in America, and 1 in Oceania. Koerner JC, George MJ, Meyer DR, Rosco MG, Habib MM. Eye (Lond). However, the results of recently published studies on ISBCS revealed that when the guidelines for strict separation of the two surgical procedures were followed, as well as after separate bilateral cataract surgeries less than five days apart, no simultaneous bilateral endophthalmitis was detected [18,19]. For overall incidence of endophthalmitis after PCS, the Meta-analysis yielded a pooled estimate of 0.092% (95%CI: 0.083%-0.101%). The differences between the incidences of acute, chronic, and the total number of POE during 20102015 were statistically significant (p = 0.0018, p = 0.0147, and p = 0.0000, respectively) with a temporal increase in the incidence of POE during 20112013. An official website of the United States government. 412-877-4519. Borkenstein AF, Packard R, Dhubhghaill SN, Lockington D, Donnenfeld ED, Borkenstein EM. Bookshelf An official website of the United States government. Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis. Postcataract endophthalmitis in South India incidence and outcome. Online ahead of print. Comparative Effectiveness of Antibiotic Prophylaxis in Cataract Surgery. The publication bias was assessed by Egger's linear regression and Begg's rank correlation tests[18][19]. Acute endophthalmitis was diagnosed if the symptoms occurred within 142 days after cataract surgery and chronic endophthalmitis was diagnosed if the symptoms occurred 43 days after cataract surgery. Compared with other cataract surgery techniques, phacoemulsification is generally considered a safe procedure with fewer complications and rapid visual rehabilitation[2]. Patient age, gender, race, and CCI were associated with risk of endophthalmitis. Postoperative nosocomial endophthalmitis: is perioperative antibiotic prophylaxis advisable? Population-based review of Medicare beneficiary claims data. Chronic POE was also significantly associated with male sex (OR 1.28, 95% CI 1.081.53) as well as with type II diabetes mellitus (OR 1.42, 95% CI 1.181.75), extracapsular cataract extraction (OR 3.09, 95% CI 2.204.23), and one-day surgery (OR 0.75, 95% CI 0.610.91). 2014 Aug;121(8):1634-42. doi: 10.1016/j.ophtha.2014.02.001. cataract, corneal, glaucoma, retinal, and of intravitreal injections, e.g. Results: WebThe size of incision was 6.57.5 mm. 2022 Apr;129(4):e39-e40. The incidence shows a decreasing trend over the past 30y, resulting in a total 1/3 reduction. WebChronic postoperative endophthalmitis is the long-term inflammation caused by the infection of the organism, which occurs after six weeks of the cataract surgery. Cataract cases combined with retinal surgery (OR, 2.60; 95% CI, 2.15-3.16) and those performed when the Charlson Comorbidity Index (CCI) was greater than 0 also had an increased likelihood of developing endophthalmitis. Clear corneal incision, an important step in modern cataract surgery: a review. On multivariable analysis, the risk of endophthalmitis after cataract surgery was increased for cases performed among those aged 75 years versus those aged <75 years (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.11-1.18), Blacks (OR, 1.13; 95% CI, 1.07-1.20), Native Americans (OR, 1.43; 95% CI, 1.19-1.73), and eyes with any history of invasive glaucoma surgery (OR, 1.40; 95% CI, 1.18-1.65). Int J Ophthalmol. FOIA [Infections after intraocular lens surgery: implications for refractive surgery]. The data were statistically analyzed. In a Keywords Immediate sequential bilateral cataract surgery Intracameral antibiotics Postoperative endophthalmitis Abbreviations and Acronyms AB antibiotic AMD age-related macular degeneration CI confidence
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