A prospective cohort study on antioxidant and folate intake and male lung cancer risk. Yaping Z, Wenlia Y, Weile K, Ying Y. Antiinflammatory and anticoagulant activities of lycopene in mice. [227] showed that inulin reduced biological compounds related with colonic cancer, such as decreased colorectal cell proliferation and water caused necrosis, lowered exposure to genotoxins, and reduced interleukin-2 release. In this study, cancer prevention by some of functional foods and the possible mechanisms of action are summarized in Table 1. Bethesda, MD 20894, Web Policies Zhang Z, Zhang P, Hamada M, Takahashi S, Xing G, Liu J, Sugiura N. Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Liu RH. Lycopene has been documented to prevent human cancer cell growth by interfering with the growth factors receptor signaling and cell cycle progression, specifically in prostate cancer cells, without known evidence of toxic impacts or cell apoptosis [79]. Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and up-regulation of p21waf1/cip1 and Wee1. Schatzkin A, Park Y, Leitzmann MF, Hollenbeck AR, Cross AJ. A review of anti-infective and anti-inflammatory chalcones. Global histone modification patterns predict risk of prostate cancer recurrence. They can be classified into many different subclasses, each subclass divided to different compounds: anthocyanidins, chalcones, flavanols, flavones, flavanones, flavonols, flavononols, and isoflavones [264,265]. Conaway CC, Yang YM, Chung FL. Kozuki Y, Miura Y, Yagasaki K. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Also, the transactivation of the RAR enhancer through -apo-14-carotenoic acid shows to occur by its metabolism to all-trans-retinoic acid [125]. In: Abelson JN, Simon MI, editors. Yang CM, Lu IH, Chen HY, Hu ML. An alternative excentric cleavage pathway was also showed [188,119] and confirmed by molecular identification of an excentric cleavage enzyme, -carotene 9, 10-monooxygenase (CMO2) in mice, humans, and zebrafish [120]. Identification of potential protein targets of isothiocyanates by proteomics. Severe serotonin syndrome can cause death if not treated. Lycopene has multiple conjugated double bonds and it act as a powerful antioxidant and free radical quencher. Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK. Narisawa et al. Narisawa T, Fukaura Y, Oshima S, Inakuma T, Yano M, Nishino H. Chemoprevention by the oxygenated carotenoid -cryptoxanthin of N-methylnitrosourea induced colon carcinogenesis in F344 rats. [86] showed that the anti-proliferative effect of lycopene on human prostate cancer cells (LNCaP) involves the activation of the PPAR-LXR-ATP-binding cassette transporter 1 (ABCA1) pathway. The authors are grateful to Prof. Dr. Muhammad Azam Kakar for criticism reading and editing of this manuscript. Due to the absence of P-ionone ring in the lycopene structure, it lacks provitamin-A activity [67]. Gajalakshmi V, Whitlock G, Peto R. Social inequalities, tobacco chewing, and cancer mortality in south india: a case-control analysis of 2,580 cancer deaths among non-smoking non-drinkers. There is a significant decrease in expression of connexins, including connexin43 in human tumors compared to normal tissue. The .gov means its official. A food-drug interaction is the consequence of a physical, chemical, or physiologic relationship between a drug and a product consumed as food or a nutrient present in a botanically-derived food or dietary supplement [ 1 ]. In a skin tumorigenesis study done by Murakoshi et al. Soon Park J, Chew BP, Wong TS. There is a study showing fucoxanthin influences multiple enzymes involved in fat metabolism causing an elevating in the production of energy from fat [171]. Holzbeierlein JM, McIntosh J, Thrasher JB. NRF2 stimulates anti-stress signaling with protective response to suppress oxidative or electrophilic stress and prevents carcinogenesis [193]. This xanthophyll also induced selected P450 enzymes in rat lung and kidney tissues, but not in the small intestine [163]. In: Bidlack WR, Tokuda H, Satomi Y, editors. Inflammation causes cancer by several mechanisms including the production of free radicals by inflammatory cells [5]. Carotenoids and chronic diseases. Cancer prevention by carotenoids. Gerber M. Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. Interestingly, combination of green tea polyphenols and sulforaphane significantly lowered cellular proliferation, likely by the pronounced impact of histone modifications as well as DNA demethylation-mediated ER activation in MDA-MB-231 cells [209]. Bingham S. The fibre-folate debate in colorectal cancer. Potential health-promoting effects of astaxanthin: a high value carotenoid mostly from microalgae. Stahl W, Sies H. Lycopene: a biologically important carotenoid for humans? On the basis of epidemiological studies, people who use diets high in omega-3 fatty acids may experience a lower prevalence of some types of cancer [257,258] and some studies have tried to evaluate the impacts of omega-3 fatty acids on cancer treatment through omega-3 supplementing to the diet either as omega-3 fatty acid-rich foods or as dietary supplements [259,260]. It has been reported to possess growth inhibitory effects in several cancer lines, including breast, colon, skin, thyroid, and leukemia cells [292,293]. In a study, Narisawa et al. Shannon J, King IB, Moshofsky R, Lampe JW, Gao DL, Ray RM, Thomas DB. These oxidants totally participate to aging and degenerative diseases such as cancer and atherosclerosis by oxidation of DNA, proteins and lipids [4]. In vitro and in vivo inhibition of. High serum carotenoids are inversely associated with serum gamma-glutamyltransferase in alcohol drinkers within normal liver function. Implementation of timeline reforms speeds initiation of national cancer institute-sponsored trials. Liu CL, Chiu YT, Hu ML. On the basis of these studies phenolic flavonoids such as green tea polyphenols and epigallocatechin-3-gallate [280,281] act as anticancer agents through activating transcription system. There is evidence showing that astaxanthin may inhibit the development of preneoplastic liver cell lesions induced by AFB1 in rats by the deviation of AFB1 metabolism towards detoxification pathways [59]. Plant estrogens: importance in health and disease. The evaluation of cancer will indicate where cancer treatment is ineffective and wasteful, and offer alternative cancer care packages that are cost-effective and suited to low-resource settings. Chang KL, Kung ML, Chow NH, Su SJ. Virus infection and human cancer: an overview. Of course functional foods not only involved phytochemicals, but there is other substances act similar functional foods. Mezuk B, Chen Y, Yu C, Guo Y, Bian Z, Collins R, Chen J, Pang Z, Wang H, Peto R, Que X, Zhang H, Tan Z, Kendler KS, Li L, Chen Z. Depression, anxiety, and prevalent diabetes in the Chinese population: findings from the China Kadoorie Biobank of 0.5 million people. Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects. Prebiotics are non-digestible food compositions that may have positive impact by the improvement of the intestinal flora. Flaxseed is emerging as an important functional food ingredient because of its rich contents of -linolenic acid (ALA, omega-3 fatty acid), lignans, and fiber. Martin HD, Choi J, Pothoulakis C. Anti- and prooxidant properties of carotenoids. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Slattery et al. Hunter DJ, Reddy KS. Both type 1 and type 2 diabetes. Astaxanthin has capacity to cross the blood brain barrier and scavenge free radicals in the brain and thus providing neuro-protection [41]. Gerber [261] reviewed prospective and case-control studies evaluating the possible protective impacts of the dietary consumption of omega-3 fatty acids on cancer development. Nutrition and lung cancer. Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects. Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Lycopene found in watermelon, grapefruit, apricots, pink guava, pawpaw, tomatoes and tomato based products account for more than 85% of lycopene in most diets [70]. Tofu and risk of breast cancer in Asian-Americans. Yasui Y, Hosokawa M, Mikami N, Miyashita K, Tanaka T. Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ, Birt DF. Dietary fibers classified into soluble or insoluble. Canthaxanthin has also proved effective at preventing both oral and colon carcinogenesis in rats [53,54]. Although it is a potent antioxidant, the chemopreventive impacts of canthaxanthin may also be associated to its ability to up-regulate gene expression, resulting in increased gap junctional cell-cell communication [158,159]. Prostate tissue lycopene content was 47% more in the lycopene group. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Careers, Unable to load your collection due to an error. Wu QJ, Yang Y, Vogtmann E, Wang J, Han LH, Li HL, Xiang YB. Batieha AM, Astorg P, Shigenaga MK. Flavonoids (genistein), stilbenes (resveratrol), polyphenols (curcumin), and isothiocyanates all have been shown to causing apoptosis in cancer cells preferentially over normal cells [205]. 9. Inclusion in an NLM database does not imply endorsement of, or agreement with, Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway. Ziegler RG. Whole wheat flour, the bran/germ fraction contributed of total -cryptoxanthin [141]. Histone deacetylase inhibitors: potential in cancer therapy. Canthaxanthin is a superior antioxidant and scavengers of free radicals when compared with the carotenoids such as -carotene [50]. Limer JL, spiers V. Phyto-estrogens and breast cancer chemoprevention. They are lower in mercury and have higher amounts of omega-3 fatty acids, which may help lower risk of heart disease and improve infant health when consumed by women during pregnancy or while breastfeeding. On the basis of reported studies, astaxanthin also increases the function of other antioxidants like Vitamin E and C [36]. It has been shown in Figure 9, enzyme myrosinase present in plant tissues or intestinal flora catalyzes the breakdown of glucosinolates such as glucoraphanin to isothiocyanate sulforaphane. Canthaxanthin has also showed cancer chemopreventive actions in UV-B-induced mouse skin tumorigenesis [167] and chemically-induced gastric [168] and breast carcinogenesis [168,169]. On the basis of these studies, sulforaphane at concentration of 75 M may cause G1/G2 cell cycle arrest and induce apoptosis through down regulating anti-apoptotic bcl-2 expression and elevating apoptosis-causing bax expression in colon cancer Caco-2 cells [199,200]. [194] showed sulforaphane and allylisothiocyanate lowered lipopolysaccharide-induced NF-B-mediated transcription of proinflammatory proteins in murine macrophages. Liang H, Lai B, Yuan Q. Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo. The Pim-1 gene involve in regulating cell differentiation and apoptosis.
Now Habersham Shooting,
Articles F