I first started on 20mg ( 1 tablet ) then 40mg, but wasn't effective. Post-SSRI sexual dysfunction, antidepressants, selective serotonin reuptake inhibitors, finasteride, isotretinoin, Enduring sexual dysfunction after treatment with antidepressants, 5-reductase inhibitors and isotretinoin: 300 cases, Persistent sexual arousal syndrome. What is post accutane syndrome? (10) If linked to an SRI, the problem starts on discontinuation of the drug. Congrats! The criteria are intended for use alongside diagnostic interviewing which should involve a detailed drug history. Clinically, tianeptine is an antidepressant effective in reducing symptoms of depression in mild to moderate-to-severe major depression, including over the long term. Post drug syndrome survivors unite - Post Accutane Syndrome, R/AccutaneDamage I am sorry to everyone suffering from finasteride, a horrible 5-AR inhibitor. The 2014 and 2018 case series from Hogan etal. Then when I discontinued Accutane, some of these effects left, but were replaced with other far more insidious side effects. The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory. Showed that, the major difference in response to sexual stimuli, in males with sexual dysfunction and normal males was a difference in the activity of the orbitofrontal cortex (2). . - Source. and Healy etal. Post-intensive care syndrome (PICS) describes a collection of health disorders that are common among patients who survive critical illness and intensive care. Nobody will bother researching conditions which they dont know exist or see no clinical benefit in treating. There should be no prior use of isotretinoin or an SRI when making a PFS diagnosis. Summary safety review oral retinoid products assessing the potential risk of impotence (erectile dysfunction). https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/, Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." ------------------------------------------------------------------------------------------------------------------------------------------------------------. Furthermore, severe PTSD twin pairsboth the trauma-exposed and unexposed membershad significantly smaller hippocampi than non-PTSD pairs., here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/, The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or the worse his mental state before the injury happened the worse his recovery will be, rather than being optimistic improves outcomes, This is pretty much all the information needed for taking this approach to curing Post-Accutane Syndrome in one place. (8) A history of efforts to have the problem treated is common. Increases muscle power and ALSO improves neuroplastictyFish Oil - improves joint pain, helps heart disease, and ALSO improves neuroplasticityZinc - increases levels of male hormones and also improves neuroplasticityMagnesium - helps with chronic pain, fatigue and insomnia and ALSO improves neuroplastictyMultivitamin - makes me less likely to be malnourished, This was originally a reply to another forum member, but I thought I may as well put it up here for others to see if they are interested, this is another example in my opinion of Accutane giving us a problem(giving us brain trauma) while hurting our ability to deal with it (lowering the amounts of neuroprotective agents in our bodies). COENZYME Q10 IN PHYSICAL EXERCISE. (2) The genital arousal is painful or altered in quality rather than pleasurable. You dont want to get into a relationship and you dont feel like you deserve one. Feel free to message me, also send over email address with your symptoms /info. It usually presents with tender, disfiguring, double or triple interconnecting comedones, cysts, inflammatory nodules, and deep burrowing abscesses on the face, shoulders, back, chest, upper arms, buttocks, and thighs. PSSD can vary in severity. Speaking of hormones, Progesterone has recently gained traction as a hormone that can assist in treating traumatic brain injury: "A large and rapidly growing body of preclinical studies suggested that PROG has neuroprotective properties in many brain injury models. The original draft was circulated to the group who made amendments based on published data, clinical and research experience, and assessment of criteria suitability across international clinical settings. And sexual experiences will no longer be psychologically arousing becoming muted. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. At present, as the data on this is limited, it is not possible to set a time limit after which an enduring condition cannot be diagnosed, particularly if all criteria are met and the clinical presentation is otherwise textbook. Is it noble for the group of people likely working harder than anyone else to alleviate the problems caused by accutane to band together, abandon their research and kill themselves in what would likely be a futile effort to get the drug removed from the market? Questions and answers: Finasteride label changes. I can only ask that we all investigate this further, but what is more important, is that we email and message researchers and neurosurgeons raising the topic of brain imaging studies and deep brain stimulation for sexual dysfunction. Please make better suggestions. (when looking up your own research on the topic these terms are virtually interchangeable, the ways to measure it are changes in brain metabolism and hippocampul growth). Hormones alone dont give you, your libido, hormones stimulate neuronal activity in specific areas of the brain, it is this activity which gives you a libido. Hopefully somehow we could get the stuff banned (though is might be kinda hard for a few years in the US with brain dead Nazis running the country). (2) An enduring change in somatic (tactile) or erogenous (sexual) genital sensation after treatment stops. Obviously I would have missed things, and thats why I want everyone to discuss and suggest things that I have missed, and while I am certain that this will wipe away many of the sides, there are other mechanisms in which accutane acted, and while this counters one way it wrecked havoc in our lives, any ideas of the things we may do to address its other issues will always be appreciated. A set of criteria were agreed upon for each of the above conditions. There are reports of PSSD and PRSD having persisted for over two decades following discontinuation of the drug[1], The criteria therefore provide no upper limit in terms of duration. Your doctor can help you choose the right skin products to reduce skin dryness and irritation. If we remain on forums and message boards, nothing will be done. SRIs, 5 alpha-reductase inhibitors and isotretinoin may cause an enduring sexual dysfunction even though prior use of the same drug or another from the same class did not produce a significant problem. ", A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression., http://www.ncbi.nlm.nih.gov/pubmed/15251924, We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss., https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/, "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. I can honestly say, I no longer have a libido or sexual desire, and I can only link this to accutane use as I have never been on other prescription meds and had normal sex drive prior to usage. If anyone has time can they research drug induced TBI and see what you can come up with. Emotional numbing or depersonalization may be a persons main complaint in primary care, but this is less likely in a sexual dysfunction clinic. Goldstein I, Komisaruk BR, Pukall CF, Kim NN, Goldstein AT, Goldstein SW It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutanes sides. PSSD is sometimes accompanied by symptoms of other pelvic conditions such as: SRIs can cause these conditions with or without sexual dysfunction. - [removed], (1) - http://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.162.5.983, (2) - https://www.ncbi.nlm.nih.gov/labs/articles/14561426/. And it does appear the brain will naturally improve with time, so for those of us with predominately psychiatric problems, there is hope. Like Accutane, alcoholism can cause reduced bloodflow in a frontal region of the brain. Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. I'm also doing some work with a survey at the moment in case you haven't seen. (4) The abnormal sensations can be triggered by non-sexual stimuli. The https:// ensures that you are connecting to the Best of luck everyone, 1(when looking up your own research on the topic these terms are virtually interchangeable, the ways to measure it are changes in brain metabolism and hippocampul growth), http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/, "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). I would appreciate it if you checked it out. "Results showed a positive relationship between perfusion levels in the left inferior frontal brain region and years of sobriety. Irritability Depression Anxiety Difficulty falling asleep Feeling slowed down Feeling in a fog or dazed Difficulty concentrating Difficulty remembering becoming fatigued easily; disordered sleep; Headache; Many people have already killed themselves after taking the drug, yet the drug remains. Mindfulness Meditation can stimulate hippocampal brain cell growth. antidepressant, accutane, isotretinoin, erectile-dysfunction, finasteride CollateralDamage February 6, 2021, 5:51pm #1 Hello guys. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Yeah, often TBIs can have a range of different effects, and thats why while I don't get half the symptoms that are displayed on this forum, I still did get more than I cared for. We need someadvice on a good but basic start off protocol. Giatti S, Diviccaro S, Panzica G, Melcangi RC. You are currently dealing with the symptoms the best you can. official website and that any information you provide is encrypted Due to getting older. . I have been doing these things for the last 5 months, and ahve noticed a great improvement in both my mental and physical health. In PSSD there is a marked escalation of genital sensory effects [22,23]. If you found out you are short sighted and needed to wear glasses, then it means now you can wear glasses, so you no longer need to suffer the symptoms of your blindness. Look Fchawk, you are not the only one who suspects TBI. https://www.ncbi.nlm.nih.gov/pubmed/20504161 "TBIs increases long-term mortality and reduces life expectancy. I personally feel really good for about a week when supplementing vitamin a then crash.2. inyour opinion what supplements/drug/etc have made a difference to recovery? Feel pretty much 100%, but I think the routine* I am following is very healthy in general, and I make sure not do overdo it, because more isn't always better. Khera M, Than JK, Anaissie J, Antar A, Song W, Losso B Nice post. These states may endure, but they are not PSSD. Ten of these patients were evaluated to have organic brain damage. My life and my future doesnt seem so hopeless, there is plenty to celebrate and Im sure plenty I will celebrate in the future, Ketogenic Diet: Improves body composition, can help ED, and ALSO improves neuroplasticity, Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help, Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121947/. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. Isotretinoin is a retinoid medication used in the treatment of acne and has been linked to sexual dysfunction in the literature [37,38]. ", Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: a double-blind, crossover placebo-controlled study. More detailed information about PGAD is available in a recently published consensus article by the International Society for the Study of Womens Sexual Health (ISSWSH)[26]. Additional isotretinoin effects that can occur independently of any sexual difficulties but may also accompany sexual problems include: The term Post-Accutane Syndrome (PAS) is in widespread use and often refers to what is termed PRSD here but equally often appears to include suicidality and other cognitive effects without sexual difficulties. I hadnt heard of Tianeptine before, but seems very interesting Not only does it promote neurogenesis, but it can also aid in asthma, which is something that Ive had to deal with since I had accutane and notice a lot because it flares up so often whenever I try to play sport, , and it also helps with IBS I know I said I wasnt really interested in antidepressants, but that in particular shows a lot of potential. I'm having a nightmare with my mild acne at the moment. Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and this one supports Taurine use as well. This has been shown in many other animals as well as humans, and is now becoming a prominent way to treat many mental illnesses. Tianeptine prevents or reverses stress-associated structural and cellular changes in the brain and normalizes disrupted glutamatergic neurotransmission. et al. Women may have a history of desperate remedies tried, and many will be members of online support forums. Post accutane syndrome (PAS), much like post finasteride syndrome, is chronic and often debilitating changes to psychology after taking the medication. et al. This was updated in 2012 to include libido disorders, ejaculation disorders and orgasm disorders that continued after discontinuation of Propecia, and decreased libido that continued after discontinuation of Proscar[33]. This seems to overlap with findings from a major PFS study[25]. SmithKline Beecham. While the ability to diagnose adverse effects should be part of any prescribers skill set, the fact that these conditions can persist or emerge upon stopping the causative drug adds an extra level of complexity. However, that is because not everyone suffers the same side effects. The treatment history is likely to include gabapentinoids, SSRIs for their genital anesthetic effect, opioids, botox, and more drastic interventions up to clitoridectomy and pudendal nerve ablation. That said 5000IU can't hurt, I was taking much more than that, I think it was around 100,000IU/day for a few weeks. 8600 Rockville Pike But again, it is not clear whether these were present before treatment. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. It cleared up my skin but stole my sex drive. 22 years old Post Accutane Syndrome (maybe there is hope?) October 18, 2021 By VeganAcneSufferers When under the care of your dermatologist or doctor, Isotretinoin or Accutane is mostly considered safe and one of the most effective treatments for severe acne. -Source. I've read mixed reviews on the accutane repair thread and can't seem to find an answer. They risk further investigations and potentially unhelpful, even damaging, treatment if a link to prior SRI or related treatment (where present) is not recognised. This is not PSSD. Almost completely cured? As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Thanks for sharing this and your experience.Having spoken to you many times I know you have worked hard on diet and exercise and all your supplements are safe ones - nothing too drastic.Funnily enough I have been watching many of Dr Mark Gordon youtube discussions, a world leader in TBI and PTSD.I am not pushing clomid but I know it is one of his protocols and I am sure I posted this recently.He says that some people with TBI have practically no T and also states that PTSD sufferers have altered hormones.You have obviously been doing some great research and i really appreciate that you have shared this with us. To develop diagnostic criteria for post-SSRI sexual dysfunction (PSSD), persistent genital arousal disorder (PGAD) following serotonin reuptake inhibitors, post-finasteride syndrome (PFS) and post-retinoid sexual dysfunction (PRSD). A recent study in humans found evidence that there may be similar implications for people exposed to an SSRI in childhood[43]. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. No psychiatric condition causes genital numbness or irritability to the point that clitoridectomy might be contemplated. Interstitial cystitis/painful bladder syndrome in men, often diagnosed as recurrent prostatitis. Norepinephrine reuptake inhibitors produce erectile dysfunction which may persist in some instances. It is important to enquire about changes in tactile and erogenous genital sensation, as well as changes in orgasm sensation, as these sensory changes seem distinctive to PSSD. Today I'm healthy and hearty, but not thanks to vitamin A, Creatine - increases Dihydrotestosterone (DHT) and testosterone. At present there are no data on the proportion of people who define themselves as asexual and have a condition that may be linked to medications. Also I would say that everything that I listed before in my post to promote neuroplasticity, is a natural antidepressant. These include antibiotics, anti-hypertensives, antidepressants, lipid lowering agents, medicines affecting endocrine systems and others[1]. Received 2021 Apr 30; Accepted 2021 Oct 7. HP/85/33/A. In a few decades though I think this will become mainstream knowledge, https://www.ncbi.nlm.nih.gov/pubmed/16425236, The hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Bremner et al, is one of the only studies which looked into functional brain imaging of patients treated with accutane (Isotretinoin) (1).This study revealed that Isotretinoin specifically altered the activity and metabolism of a brain region called the orbitofrontal cortex in those who took Isotretinoin versus controls. Increased dendritic branching occurs in the basolateral nucleus of the amygdala. In contrast, antipsychotics cause sexual difficulties including a loss of sexual desire, erectile dysfunction, retrograde ejaculation and other problems. Before I did the work still expecting to fail, while now I do the work and I expect success, which makes me actually enjoy the work, and thats just one example. https://www.ncbi.nlm.nih.gov/pubmed/20504161, Ketogenic Diet research article (contains research on how keto diet resets brain metabolism after TBI and how it is neuroprotective), https://www.ncbi.nlm.nih.gov/books/NBK209323/?report=classic, Will add more stuff to OP over time, and reformat it as well. The efficacy profile of tianeptine could be explained by its neurobiological properties observed in animal models. Whether these changes are part of the syndrome or co-incidental is uncertain. (1) Prior treatment with a 5 alpha-reductase inhibitor. a possible means, along with positive emotions, reduced oxidative damage, by which meditation may preserve cognition, and reduce age-related allostatic stress and neuronal loss, thereby promoting brain longevity, plasticity, and learning). Otherwise I am a healthy, athletic male, who has experimented with high levels of testosterone as well as other drugs but to no avail. PFS guys considering it too.[removed]. EDIT: I was probably the best I'd been since I was 16, probably more like 95%. I think for the last two months I have woken with morning wood 95% of the time, social anxiety is limited, confidence in my abilities in much higher, and motivation to reach my goals, and also willingness to do the work to reach them, is also one of the main things I have noticed. HHS Vulnerability Disclosure, Help If a patient had prior sexual difficulties, it is important to decide on the degree of overlap to the current problem. For example, in the case of SSRIs, premature ejaculation seems to be most closely associated with stopping the drug. omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients, may be helpful in the recovery from a a TBI", Vitamin D: Improves bone health, physical fitness, and ALSO improves neuroplasticity, ]. Well certainly the people that make it claim to know nothing. sotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. If youre suffering these symptoms as a consequence of the accutane its important to not give up hope and know that there are solutions. The original draft was designed using data from two published case series (Hogan etal., 2014 and Healy etal., 2018), which represent the largest public collections of data on these enduring conditions. (5) Spontaneous unwelcome and unpleasant orgasmic events. https://www.ncbi.nlm.nih.gov/pubmed/24215918, Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations. PGAD is commonly seen in pain clinics. All rights reserved. There should be no prior use of finasteride or an SRI when making a PRSD diagnosis. Notice the distinction made there. In 2011, a warning for erectile dysfunction that persisted after stopping treatment was added to the US product label for the finasteride products, Propecia and Proscar. "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Thank you so much Fchawks for all the hard work and the great information that you have shared. There is no justice here, and I doubt there is going to be a happy end to this story. A degree of discretion may be warranted in such cases when assessing a possible link to the medication. For each of these conditions, it is now clear that cases had been reported or were present for a decade or more before appearing in the academic literature. irritability or aggression on little or no provocation; anxiety, depression, or affective instability; changes in personality (eg, social or sexual inappropriateness); or. Dee Mangin is supported by the David Braley Chair in Family Medicine, McMaster University. sharing sensitive information, make sure youre on a federal We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Several have successfully petitioned regulators in North America and Europe on the issue of PSSD, resulting in warnings about persistent sexual dysfunction after discontinuation of treatment being added to medication labels[15]. Summary: Post concussion syndrome is found among people who take Accutane, especially for people who are male, 10-19 old, have been taking the drug for 6 - 12 months. The Ketogenic Diet also helps promote Neuroplasticity, and many people who go on that diet who struggle with libido problems and are on antidepressants recover over the months and years they are on that diet.
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